| ACE | Advanced Composition Explorer | - | Atmospheric Research Center |
| ACE | Aerosol Characterization Experiment | - | Computer Acronyms(common) |
| ACE | Alliance For Clean Energy | - | Computer Acronyms(common) |
| ACE | Acidity In Cloud Experiment | - | Computer Acronyms(common) |
| ACE | Affinity Capillary Electrophoresis | - | Computer Acronyms(common) |
| ACE | Alternating Conditional Expectations | - | Computer Acronyms(common) |
| ACE | Angiotensin-converting Enzyme | - | Computer Acronyms(common) |
| ACE | Atmospheric Collection Equipment | - | Computer Acronyms(common) |
| ACE | Angiotensin-converting Enzyme | - | Medical |
| ACE | Angiotensin Converting Enzyme | - | Medical(slang) |
| ACE | Access Control Entry | - | ISO Country Codes |
| ACE | Air Combat Emulator (computer Game) - Allied Command Europe - Armored Combat Earthmover - Automatic Computing Engine | - | Astronomy |
| ACE | Alliance For Clean Energy | - | Business and Finance |
| ACE | American Council On Education | - | Business and Finance |
| ACE | Antarctic Current Experiment | - | Business and Finance |
| ACE | Aerosol Characteristics Experiment | - | Business and Finance |
| ACE | Accelerated Computing Environment | - | Business and Finance |
