| IOC | In-Orbit Checkout And Calibration | - | Atmospheric Research Center |
| IOC | Intergovernmental Oceanographic Commission | - | Computer Acronyms(common) |
| IOC | Inorganic Chemical | - | Computer Acronyms(common) |
| IOC | Indirect Operating Costs | - | Organizations |
| IOC | Initial Operational Capability | - | Organizations |
| IOC | Input/Output Controller | - | Organizations |
| IOC | Joint Operations Center | - | Organizations |
| IOC | Instructor Orientation Course (PADI) | - | SMS Chat and Text |
| IOC | Initial Operational Capability - Intergovernmental Oceanic Commission - International Olympic Committee - International Ornithological Congress | - | Astronomy |
| IOC | Intergovernmental Oceanographic Commission | - | Business and Finance |
| IOC | International Ozone Commission | - | Business and Finance |
| IOC | Inception Of Contract | - | Business and Finance |
| IOC | Initial Operating Capability | - | Business and Finance |
| IOC | inter-office channel
| - | Human Genome |
