| IRIS | Incorporated Research Institutes For Seismology | - | Computer Acronyms(common) |
| IRIS | Imaging Of Radicals Interacting With Surfaces | - | Computer Acronyms(common) |
| IRIS | Infrared Interferometer Spectrometer | - | Computer Acronyms(common) |
| IRIS | Integrated Risk Information System | - | Computer Acronyms(common) |
| IRIS | Infrared Radiation Interferometer Spectrometer (1960s) | - | Scuba Diving |
| IRIS | Infrared Interferometer Spectrometer | - | Business and Finance |
| IRIS | Incorporated Research Institutions For Seismology | - | Business and Finance |
| IRIS | Italian Research Interim Stage | - | Business and Finance |
