| IRS | Infrared Soldering | - | Computer Acronyms(common) |
| IRS | Insulin Receptor Substrate | - | Computer Acronyms(common) |
| IRS | Interferon-responsive Sequence | - | Computer Acronyms(common) |
| IRS | Internal Recognition Subsequence | - | Computer Acronyms(common) |
| IRS | Internal Reflection Spectroscopy | - | Computer Acronyms(common) |
| IRS | Inverse Raman Scattering | - | Computer Acronyms(common) |
| IRS | U.S. Internal Revenue Service | - | Astronomy |
| IRS | Indian Remote-sensing Satellite | - | Business and Finance |
| IRS | Information Retrieval Service | - | Business and Finance |
| IRS | Internal Revenue Service
| - | Human Genome |
