| SAM | Shuttle Activation Monitor | - | Atmospheric Research Center |
| SAM | Scanning Auger Microscopy | - | Computer Acronyms(common) |
| SAM | Sterile Alpha Motif | - | Computer Acronyms(common) |
| SAM | Stratospheric Aerosol Monitor | - | Computer Acronyms(common) |
| SAM | Scanning Acoustic Microscopy | - | Computer Acronyms(common) |
| SAM | Self-assembled Monolayer | - | Computer Acronyms(common) |
| SAM | SAMPShuttle Automated Mass Properties | - | Organizations |
| SAM | SAMSShuttle Attachment ManiPulator SYstem | - | Organizations |
| SAM | Shuttle Attachment ManiPulator | - | Organizations |
| SAM | SYstem Activation And Monitoring | - | Organizations |
| SAM | Sequential-Access Memory - Sociedad Aeronÿutica De MedellÂn - Surface-to-Air Missile | - | Astronomy |
| SAM | Subsynoptic Advection Model | - | Business and Finance |
| SAM | Sun-angle Magnetometer | - | Business and Finance |
| SAM | Stratospheric Aerosol Measurement | - | Business and Finance |
| SAM | SCSI-3 Architecture Model
| - | Human Genome |
