| SME | Solar Mesosphere Explorer | - | Atmospheric Research Center |
| SME | Small And Medium Enterprises | - | Chatting Acronyms |
| SME | Solar Mesosphere Explorer | - | Computer Acronyms(common) |
| SME | Shape Memory Effect | - | Computer Acronyms(common) |
| SME | Solid-metal Embrittlement | - | Computer Acronyms(common) |
| SME | Static Model Exchange (approxn. In Electron-mol. Scattering) | - | Computer Acronyms(common) |
| SME | Subject Matter Expert | - | ISO Country Codes |
| SME | Scan Mirror Electronics - Subject Matter Expert | - | Astronomy |
| SME | Northern Sami Language (ISO 639-2 Code) | - | Astronomy |
| SME | Solar Mesosphere Explorer | - | Business and Finance |
| SME | Stratosphere-Mesosphere Explorer Satellite | - | Business and Finance |
| SME | subject matter expert
| - | Human Genome |
