| E | East | - | Astronomy |
| E&E | Escape And Evasion (training) | - | Astronomy |
| E&OE | Errors And Omissions Excepted | - | Astronomy |
| E.G. | Exampla Gratia (Latin | - | Astronomy |
| E? OR E3 | Many | - | Astronomy |
| EA | Electronic Attack - Engagement Area - Electronic Arts - Environmental Assessment -Exaampere | - | Astronomy |
| EABU | Explain Acronyms Before Use | - | Astronomy |
| EAC | Echelons Above Corps | - | Astronomy |
| EAFUS | Everything Added To Food In The United States (FDA List) | - | Astronomy |
| EAPC | Euro-Atlantic Partnership Council | - | Astronomy |
| EASA | European Aviation Safety Agency | - | Astronomy |
| EAST | Experimental Advanced Superconducting Tokamak | - | Astronomy |
| EBCDIC | Extended Binary Coded Decimal Interchange Code (pronounced Eb-see-dik) (cf. BCD) | - | Astronomy |
| EBD | Electronic Brake Distribution | - | Astronomy |
| EBE | Extraterrestrial Biological Entity | - | Astronomy |
| EBO | Effects Based Operations - Encyclop?dia Britannica Online - European Board Of Ophthalmology | - | Astronomy |
| EBW | Electron Beam Welding | - | Astronomy |
| EBW | Exploding BridgeWire | - | Astronomy |
| EC | Ecuador (ISO 3166 Digram; FIPS 10-4 Country Code) -Electronic Combat - European Community (see EEC) -Exacoulomb | - | Astronomy |
| ECB | European Central Bank - England (and Wales) Cricket Board | - | Astronomy |
| ECBR | European Coalition For Biomedical Research | - | Astronomy |
| ECCM | Electronic Counter-Counter-Measures | - | Astronomy |
| ECHO | Each Community Helps Others (EPA Programme) - Educational Concerns For Hunger Organization - European Commission Host Organization - European Commission Humanitarian Aid Office -Exchange Clearing House - Expanded Characteristic Option -Explanatory Coheren | - | Astronomy |
| ECHR | European Convention On Human Rights | - | Astronomy |
| ECJ | European Court Of Justice | - | Astronomy |
| ECL | Emitter Coupled Logic (electronics) | - | Astronomy |
| ECM | Electronic Counter-Measures - Enterprise Content Management | - | Astronomy |
| ECOMMHR | European Commission On Human Rights | - | Astronomy |
| ECS | Emergency Contact System - Enhanced Chip Set (computing) - EOSDIS Core System - Extended Chip Set (computing) | - | Astronomy |
| ECSC | European Coal And Steel Community (distant Ancestor Of The EU) | - | Astronomy |
| ECT | ElectroConvulsive Therapy | - | Astronomy |
| ECTHR | European Court Of Human Rights | - | Astronomy |
| ECU | Ecuador (ISO 3166 Trigram) -European Currency Unit (ancestor Of The Euro) | - | Astronomy |
| ECW | Eastern Championship Wrestling - Extreme Championship Wrestling | - | Astronomy |
| EDA | European Defence Agency | - | Astronomy |
| EDAC | Error Detection And Correction | - | Astronomy |
| EDC | DAAC -EROS Data Center Distributed Active Archive Center | - | Astronomy |
| EDCS | Environmental Data Coding Specification | - | Astronomy |
| EDECSIM | Extended Directed Energy Combat Simulation | - | Astronomy |
| EDH | Eastman Dental Hospital | - | Astronomy |
| EDS | Electronic Data Systems - Electronic Differential System | - | Astronomy |
| EDSA | Epifanio De Los Santos Avenue (a Major Thoroughfare In Manila With Great Significance To Post-1980 Philippines History) | - | Astronomy |
| EDT | Eastern Daylight Saving Time (UTC-4 Hours) | - | Astronomy |
| EDTA | Electric Drive Transportation Association -EthyleneDiamineTetraAcetic Acid | - | Astronomy |
| EE | Estonia (ISO 3166 Digram) -Electrical Engineering - Electrical Engineer | - | Astronomy |
| EE | Ewe Language (ISO 639-1 Code) | - | Astronomy |
| EEC | European Economic Community (predecessor Of The EU) | - | Astronomy |
| EEG | ElectroEncephaloGram | - | Astronomy |
| EEK | Estonian Kroon (ISO 4217 Currency Code) | - | Astronomy |
| EEZ | Economic Exclusion Zone Or Exclusive Economic Zone | - | Astronomy |
| EF | Entry Foyer | - | Astronomy |
| EF | Exafarad | - | Astronomy |
| EFF | Electronic Frontier Foundation | - | Astronomy |
| EFL | English As A Foreign Language | - | Astronomy |
| EFOA | European Fuel Oxygenates Association | - | Astronomy |
| EFSA | European Food Safety Authority | - | Astronomy |
| EFT | Electronic Fund Transfer | - | Astronomy |
| EFV | Expeditionary Fighting Vehicle | - | Astronomy |
| EG | Egypt (ISO 3166 Digram; FIPS 10-4 Country Code) | - | Astronomy |
| EGBUS | External Genitalia | - | Astronomy |
| EGCG | EpiGalloCatechin-3-Gallate | - | Astronomy |
| EGIS | Erieye Ground Interface Segment | - | Astronomy |
| EGP | Egyptian Pound (ISO 4217 Currency Code) | - | Astronomy |
| EGRET | Energetic Gamma-Ray Experiment Telescope | - | Astronomy |
| EGY | Egypt (ISO 3166 Trigram) | - | Astronomy |
| EH | Exahenry - Western Sahara (ISO 3166 Digram) | - | Astronomy |
| EHF | Extremely High Frequency | - | Astronomy |
| EHR | Equipment History Record | - | Astronomy |
| EI | Exbi | - | Astronomy |
| EI | Ireland (FIPS 10-4 Country Code; From Âire) | - | Astronomy |
| EIA | Environmental Impact Assessment | - | Astronomy |
| EIAH | Encyclopedia Of Iranian Architectural History | - | Astronomy |
| EIAH | Environnements Informatiques Pour L'Apprentissage Humain | - | Astronomy |
| EIC | East India Company | - | Astronomy |
| EICS | East India Company's Service | - | Astronomy |
| EID | Electronic ID | - | Astronomy |
| EIRP | Effective Isotropic Radiated Power | - | Astronomy |
| EIS | Environmental Impact Statement | - | Astronomy |
| EJ | Exajoule | - | Astronomy |
| EK | Equatorial Guinea (FIPS 10-4 Country Code) - Exakelvin | - | Astronomy |
| EKG | Electrocardiogram (from German Elektrokardiogramm) | - | Astronomy |
| EKMS | Electronic Key Management System | - | Astronomy |
| EL | Exalitre | - | Astronomy |
| EL | Greek Language (ISO 639-1 Code) | - | Astronomy |
| ELF | Earth Liberation Front - Endangered Language Fund - Eritrean Liberation Front - Executable And Linkable Format - Extremely Low Frequency | - | Astronomy |
| ELINT | Electronic Intelligence | - | Astronomy |
| ELL | Greek Language (ISO 639-2 Code) | - | Astronomy |
| ELM | Edge-Localised Mode (plasma Physics) | - | Astronomy |
| ELP | Emerson Lake And Palmer | - | Astronomy |
| ELSS | Emergency Life Support Stores | - | Astronomy |
| ELT | Emergency Locator Transmitter | - | Astronomy |
| EM | ElectroMagnetism/ElectroMagnetic | - | Astronomy |
| EM | Exametre | - | Astronomy |
| EMA | European Medicines Agency | - | Astronomy |
| EMC | Electric Membership Corporation - Electromagnetic Compatibility - Electro-Motive Corporation - European Muon Collaboration - Evergreen Marine Corporation | - | Astronomy |
| EMCON | (Electromagnetic) Emissions Control | - | Astronomy |
| EMD | Electro-Motive Diesel - Engineering And Manufacturing Development - European Missile Defence | - | Astronomy |
| EMDG | Euro-Missile Dynamics Group | - | Astronomy |
| EMDR | Eye Movement Desensitisation And Reprocessing | - | Astronomy |
| EMEA | Europe | - | Astronomy |
