| SAN | Storage Area Network | - | Computer and Internet |
| SATA | Serial Advanced Technology Attachment | - | Computer and Internet |
| SCSI | Small Computer System Interface | - | Computer and Internet |
| SD | Secure Digital | - | Computer and Internet |
| SDRAM | Synchronous Dynamic Random Access Memory | - | Computer and Internet |
| SDSL | Symmetric Digital Subscriber Line | - | Computer and Internet |
| SEM | Search Engine Marketing | - | Computer and Internet |
| SEO | Search Engine Optimization | - | Computer and Internet |
| SIMM | Single In-Line Memory Module | - | Computer and Internet |
| SKU | Stock Keeping Unit | - | Computer and Internet |
| SLI | Scalable Link Interface | - | Computer and Internet |
| SMART | Self-Monitoring Analysis And Reporting Technology | - | Computer and Internet |
| SMB | Server Message Block | - | Computer and Internet |
| SMS | Short Message Service | - | Computer and Internet |
| SMTP | Simple Mail Transfer Protocol | - | Computer and Internet |
| SNMP | Simple Network Management Protocol | - | Computer and Internet |
| SO-DIMM | Small Outline Dual In-Line Memory Module | - | Computer and Internet |
| SOA | Service Oriented Architecture | - | Computer and Internet |
| SOAP | Simple Object Access Protocol | - | Computer and Internet |
| SQL | Structured Query Language | - | Computer and Internet |
| SRAM | Static Random Access Memory | - | Computer and Internet |
| SRGB | Standard Red Green Blue | - | Computer and Internet |
| SSH | Secure Shell | - | Computer and Internet |
| SSID | Service Set Identifier | - | Computer and Internet |
| SSL | Secure Sockets Layer | - | Computer and Internet |
