| E | East | - | Organizations |
| E | LACS Extended Life Attitude Control System | - | Organizations |
| E | LSCEarth Landing Sequence Controller | - | Organizations |
| E | LSSEmergency Life Support System | - | Organizations |
| E&D | Engineering And Development | - | Organizations |
| E&D | Engineering And DeveloPment Directorate (JSC) | - | Organizations |
| E-E | End-to-End | - | Organizations |
| E-MUX | Electrical Multiplex | - | Organizations |
| E-P | Electron/Proton | - | Organizations |
| E/0-IMS | E/0-Information Management System | - | Organizations |
| E/C | Encoder/Coupler | - | Organizations |
| E/L | Entry/Landing | - | Organizations |
| E/M | Engineering Model | - | Organizations |
| E/O | Engineering/Operations | - | Organizations |
| E/W | Energy Over Weight | - | Organizations |
| E/W | Energy To Weight Ratio | - | Organizations |
| EA | Each | - | Organizations |
| EA | Electronic Assembly | - | Organizations |
| EA | Elevation Angle | - | Organizations |
| EAC | Energy Absorbing Capacity | - | Organizations |
| EAC | Estimate At Completion | - | Organizations |
| EAD | ElectricallY Alterable Device | - | Organizations |
| EADI | Electronic Attitude Director Indicator | - | Organizations |
| EAFB | Edwards Air Force Base | - | Organizations |
| EAFB | Edwards Air Force Base | - | Organizations |
| EAFB | Elgin Air Force Base | - | Organizations |
| EAFB | Ellington Air Force Base | - | Organizations |
| EAM | Electrical Accounting Machine | - | Organizations |
| EAR | Engineering AnalYsis Report | - | Organizations |
| EAS | Equivalent Air Speed | - | Organizations |
| EAS | Equivalent Airspeed | - | Organizations |
| EAT | Environmental Acceptance Test | - | Organizations |
| EB | Electronic Beam | - | Organizations |
| EB | Emergency Box | - | Organizations |
| EBC | Emulated Buffer COMPuter | - | Organizations |
| EBCDC | Extended Binary Coded Decimal | - | Organizations |
| EBD | Eyeballs Down (+GZ) | - | Organizations |
| EBI | Eyeballs In (+GX) | - | Organizations |
| EBL | Eyeballs Left (+GY) | - | Organizations |
| EBO | Eyeballs Out (-GX) | - | Organizations |
| EBR | Eyeballs Right (-GY) | - | Organizations |
| EBS | Emergency Breathing Subsystem | - | Organizations |
| EBU | Eyeballs Up (-GZ) | - | Organizations |
| EBW | Electron Beam Welding | - | Organizations |
| EBW | Exploding Bridge Wire | - | Organizations |
| EC | Element Contractor | - | Organizations |
| EC | Engine Control | - | Organizations |
| EC | Engine Cutoff | - | Organizations |
| EC | Essentiality Code | - | Organizations |
| EC | Events Controller | - | Organizations |
| EC | Events Coupler | - | Organizations |
| EC | Experiment Computer | - | Organizations |
| ECA | Electronics Control Assembly | - | Organizations |
| ECA | Engineering Change Analysis | - | Organizations |
| ECA | Epoxy Curing Agent | - | Organizations |
| ECAS | Experiment Computer Application Software | - | Organizations |
| ECB | Engineering Change Board | - | Organizations |
| ECB | Event Control Block | - | Organizations |
| ECB | Events Control Buffer | - | Organizations |
| ECC | Engineering Change Control | - | Organizations |
| ECC | Engineering Critical Component | - | Organizations |
| ECCB | Engineering Change Control Board | - | Organizations |
| ECD | Engineering Control Drawing | - | Organizations |
| ECD | Estimated Completion Date | - | Organizations |
| ECEP | Experiment Checkout Equipment Processor | - | Organizations |
| ECF | Element Charge Factor | - | Organizations |
| ECF | Equivalency Capability File | - | Organizations |
| ECG | Electrocardiogram | - | Organizations |
| ECG | Electrocardiograph | - | Organizations |
| ECI | Earth Centered Inertia (inertials) | - | Organizations |
| ECIO | Experiment Computer Input/Output | - | Organizations |
| ECL | Entry Closed Loop | - | Organizations |
| ECLS | Environmental Control And Life Support | - | Organizations |
| ECLSS | Environmental Control And Life Support System | - | Organizations |
| ECLSS | Environmental Control And Life Support System | - | Organizations |
| ECN | Engineering Change Notice | - | Organizations |
| ECO | Engine Combustion | - | Organizations |
| ECO | Engine Cutoff | - | Organizations |
| ECO | Engineering Change Order | - | Organizations |
| ECOS | Experiment Computer Operating System | - | Organizations |
| ECP | Engineering Change Program | - | Organizations |
| ECP | Engineering Change Proposal | - | Organizations |
| ECP | Engineering Control Proposal | - | Organizations |
| ECP | Explicitly Coded Program | - | Organizations |
| ECR | Engineering Change Request | - | Organizations |
| ECRA | Engineering Change Request/Authorization | - | Organizations |
| ECS | Engine Control SYstem | - | Organizations |
| ECS | Environmental Control System (Subsystem) | - | Organizations |
| ECU | Electrical Control Unit | - | Organizations |
| ECU | Electronic Coupling Unit | - | Organizations |
| ECU | Environmental Control Unit | - | Organizations |
| ED | Edge Distance | - | Organizations |
| ED | Edit | - | Organizations |
| ED | Engineering Directive | - | Organizations |
| ED | Explosive Device | - | Organizations |
| EDA | Electronic DisPlay Assembly | - | Organizations |
| EDA | Elevation Drive Assembly | - | Organizations |
| EDB | Environmental Data Book | - | Organizations |
| EDC | Engineering Design Change | - | Organizations |
| EDC(M) | Electrochemical DePolarized CO (Module) | - | Organizations |
