| E | Elliptical (for Galaxies) | - | Atmospheric Research Center |
| EAFB | Edwards Air Force Base | - | Atmospheric Research Center |
| ECS | Environmental Control System | - | Atmospheric Research Center |
| EDC | EROS Data Center | - | Atmospheric Research Center |
| EDO | Extended Duration Orbiter | - | Atmospheric Research Center |
| EDOMP | EDO Medical Project | - | Atmospheric Research Center |
| EDRS | European Data Relay Satellite | - | Atmospheric Research Center |
| EDS | Electronic Data Systems | - | Atmospheric Research Center |
| EGRET | Energetic Gamma Ray Experiment Telescope | - | Atmospheric Research Center |
| EJASA | Electronic Journal Of The Astronomical Society Of The Atlantic | - | Atmospheric Research Center |
| ELDO | European Launcher Development Organisation | - | Atmospheric Research Center |
| ELV | Expendable Launch Vehicle | - | Atmospheric Research Center |
| EMU | Extravehicular Mobility Unit | - | Atmospheric Research Center |
| ENAC | Energetic Neutral Atom Camera | - | Atmospheric Research Center |
| ENACEOS | ENAC For EOS | - | Atmospheric Research Center |
| ENAP | Energetic Neutral Atom Precipitation | - | Atmospheric Research Center |
| ENSO | El Nino/Southern Oscillation | - | Atmospheric Research Center |
| EODC | Earth Observation Data Centre | - | Atmospheric Research Center |
| EOS | Earth Observing System | - | Atmospheric Research Center |
| EOS | Electrophoresis Operations In Space | - | Atmospheric Research Center |
| EOSP | Earth Observing Scanning Polarimeter | - | Atmospheric Research Center |
| EPD | Energetic Particles Detector | - | Atmospheric Research Center |
| ER | Eastern Range | - | Atmospheric Research Center |
| ERBE | Earth Radiation Budget Experiment | - | Atmospheric Research Center |
| EROS | Earth Resources Observations System | - | Atmospheric Research Center |
| ERS | Earth Resources Satellite | - | Atmospheric Research Center |
| ERS | European Remote Sensing | - | Atmospheric Research Center |
| ERS | Environmental Research Satellite | - | Atmospheric Research Center |
| ESA | European Space Agency | - | Atmospheric Research Center |
| ESIS | European Space Information System | - | Atmospheric Research Center |
| ESO | European Southern Observatory | - | Atmospheric Research Center |
| ESOC | European Space Operations Centre | - | Atmospheric Research Center |
| ESPC | European Space Power Conference | - | Atmospheric Research Center |
| ESRIN | European Space Research Institute | - | Atmospheric Research Center |
| ESRO | European Space Research Organisation | - | Atmospheric Research Center |
| ESTEC | European Space Research And Technology Centre | - | Atmospheric Research Center |
| ET | External Tank | - | Atmospheric Research Center |
| ET | Ephemeris Time | - | Atmospheric Research Center |
| ETE | End-to-End | - | Atmospheric Research Center |
| ETM | Enhanced Thematic Mapper | - | Atmospheric Research Center |
| ETR | Eastern Test Range | - | Atmospheric Research Center |
| EUMETSAT | European Meterological Satellite Organisation | - | Atmospheric Research Center |
| EURECA | European Retrievable Carrier | - | Atmospheric Research Center |
| EUTELSAT | European Telecommunications Satellite Organization | - | Atmospheric Research Center |
| EUV | Extreme UltraViolet | - | Atmospheric Research Center |
| EUVE | Extreme UltraViolet Explorer | - | Atmospheric Research Center |
| EVA | Extravehicular Activity | - | Atmospheric Research Center |
