| FAP | Freedom Attached Payloads | - | Atmospheric Research Center |
| FAST | Fast Auroral SnapshoT Explorer | - | Atmospheric Research Center |
| FBV | Fuel Bleed Valve | - | Atmospheric Research Center |
| FEM | Flight-Engineering Model | - | Atmospheric Research Center |
| FFCC | Free-Flyer Control Centre | - | Atmospheric Research Center |
| FFT | Fast Fourier Transform | - | Atmospheric Research Center |
| FGS | Fine Guidance Sensors | - | Atmospheric Research Center |
| FHST | Fixed Head Star Trackers | - | Atmospheric Research Center |
| FIR | Far InfraRed | - | Atmospheric Research Center |
| FIRAS | Far InfraRed Absolute Spectrophotometer | - | Atmospheric Research Center |
| FITS | Flexible Image Transport System | - | Atmospheric Research Center |
| FOC | Faint Object Camera | - | Atmospheric Research Center |
| FOLD | Federally-Owned LANDSAT Data | - | Atmospheric Research Center |
| FOS | Faint Object Spectrograph | - | Atmospheric Research Center |
| FPD | Flight Projects Directorate | - | Atmospheric Research Center |
| FPM | Fiber Pulling In Microgravity | - | Atmospheric Research Center |
| FRC | Flight Research Center | - | Atmospheric Research Center |
| FRED | Space Station Freedom | - | Atmospheric Research Center |
| FRF | Flight Readiness Firing | - | Atmospheric Research Center |
| FRR | Flight-Readiness Review | - | Atmospheric Research Center |
| FRSI | Flexible Reusable Surface Insulation | - | Atmospheric Research Center |
| FTS | Flight Telerobotic Servicer | - | Atmospheric Research Center |
| FUSE | Far Ultraviolet Spectroscopic Explorer | - | Atmospheric Research Center |
| FWHM | Full Width At Half Maximum | - | Atmospheric Research Center |
