| EAP | Extensible Authentication Protocol | - | Human Genome |
| EBCDIC | Extended Binary Coded Decimal Interchange Code | - | Human Genome |
| ECC | Error Correction Code (Error Checking And Correction) | - | Human Genome |
| ECN | Explicit Congestion Notification | - | Human Genome |
| EDGE | Enhanced Data Rates For Global Evolution | - | Human Genome |
| EDI | Electronic Data Interchange | - | Human Genome |
| EDLC | Electrochemical Double-layer Capacitor | - | Human Genome |
| EDO RAM | Extended Data-Out Random Access Memory | - | Human Genome |
| EDP | Electronic Data Processing | - | Human Genome |
| EDRAM | Enhanced Dynamic Random Access Memory | - | Human Genome |
| EEMS | Enhanced Expanded Memory Specification | - | Human Genome |
| EEPROM | Electrically Erasable Programmable Read-Only Memory | - | Human Genome |
| EFT | Electronic Funds Transfer | - | Human Genome |
| EGA | Enhanced Graphics Adapter | - | Human Genome |
| EIA | Electronic Industries Alliance (Association) | - | Human Genome |
| EIDE | Enhanced Integrated Device Electronics | - | Human Genome |
| EIDE | Enhanced Intelligent Drive Electronics | - | Human Genome |
| EISA | Extended Industry Standard Architecture | - | Human Genome |
| ELD | Electroluminescent Display | - | Human Genome |
| ELF | Extremely Low Frequency | - | Human Genome |
| EMM | Expanded Memory Manager | - | Human Genome |
| EMS | Expanded Memory Specification | - | Human Genome |
| EOF | End Of File | - | Human Genome |
| EPP | Enhanced Parallel Port | - | Human Genome |
| EPROM | Erasable Programmable Read-Only Memory | - | Human Genome |
| EPS | Encapsulated PostScript | - | Human Genome |
| ERP | Enterprise Resource Planning | - | Human Genome |
| ESC | Escape Character | - | Human Genome |
| ESCD | Extended System Configuration Data | - | Human Genome |
| ESDI | Enhanced System Device Interface | - | Human Genome |
| ESP | Encapsulating Security Payload | - | Human Genome |
| ESP | Eudora Sharing Protocol | - | Human Genome |
| ETOX | EPROM Tunnel Oxide | - | Human Genome |
| EULA | End User License Agreement | - | Human Genome |
| EWAN | Emulator Without A Name | - | Human Genome |
| EXIF | Exchangeable Image File | - | Human Genome |
| E911 | enhanced 911
| - | Human Genome |
| E-LAN | Ethernet private local area network
| - | Human Genome |
| E-LINE | Ethernet private line
| - | Human Genome |
| E-POP | electronic-point of presence
| - | Human Genome |
| ECOS | end-to-end Class of Service
| - | Human Genome |
| ECR | enhanced call routing
| - | Human Genome |
| ECRM | electronic customer relationship management
| - | Human Genome |
| ECS | Electronic Commerce Service
| - | Human Genome |
| ECTF | Enterprise Computer Telephony Forum
| - | Human Genome |
| EDRO | enhanced diversity routing option
| - | Human Genome |
| EFMA | Ethernet in the First Mile Alliance
| - | Human Genome |
| EGP | exterior gateway protocol
| - | Human Genome |
| EIGRP | enhanced interior gateway routing protocol
| - | Human Genome |
| EIT | electronic information technology
| - | Human Genome |
| EM | element manager
| - | Human Genome |
| EMEA | Europe, Middle East, and Africa
| - | Human Genome |
| EN | Event Notification
| - | Human Genome |
| EOP | Executive Office of the President
| - | Human Genome |
| EOS | elements of service
| - | Human Genome |
| EPA | Environmental Protection Agency
| - | Human Genome |
| EPCRA | Emergency Planning and Community Right-to-Know Act of 1986
| - | Human Genome |
| ePO | ePolicy Orchestrator
| - | Human Genome |
| EPR | emergency performance routing
| - | Human Genome |
| EPRO | e-Procurement Requisition Processing
| - | Human Genome |
| ER | extended reach
| - | Human Genome |
| ERMS | Email Response Management Service
| - | Human Genome |
| ERTNR | enhanced real-time network routing
| - | Human Genome |
| ES | error second (optical)
| - | Human Genome |
| ESCON | enterprise system connection
| - | Human Genome |
| ESF | extended superframe
| - | Human Genome |
| ESMR | enhanced specialized mobile radio
| - | Human Genome |
| EthS | Ethernet Services
| - | Human Genome |
| ETR | external timing reference
| - | Human Genome |
| ETS | emergency telecommunications support
| - | Human Genome |
| ETSI | European Telecommunications Standard Institute
| - | Human Genome |
| EVC | Ethernet virtual connection, Ethernet virtual circuit
| - | Human Genome |