| S-HTTP | Secure HTTP | - | Human Genome |
| S/MIME | Secure/MIME | - | Human Genome |
| SAA | System Application Architecture | - | Human Genome |
| SAN | Storage Area Network | - | Human Genome |
| SAP | SAP America, Inc. (SAP AG) | - | Human Genome |
| SAP | Secondary Audio Program | - | Human Genome |
| SAP | Service Advertising Protocol | - | Human Genome |
| SAS | Serial Attached SCSI | - | Human Genome |
| SBB | Storage Bridge Bay Working Group | - | Human Genome |
| SCAM | SCSI Configuration Automatically | - | Human Genome |
| SCART | Syndicat Des Constructeurs D'Appareils Radior?cepteurs Et T?l?viseurs (Radio And Television Receiver Manufacturer's Association); 21-pin Connector Standard For AV (Audio-visual) Equipment | - | Human Genome |
| SCSI | Small Computer System Interface | - | Human Genome |
| SDH | Synchronous Digital Hierarchy | - | Human Genome |
| SDK | Software Development Kit | - | Human Genome |
| SDRAM | Synchronous Dynamic RAM | - | Human Genome |
| SDSL | Symmetric Digital Subscriber Line | - | Human Genome |
| SET | Secure Electronic Transaction | - | Human Genome |
| SFF | Small Form-Factor | - | Human Genome |
| SGI | Silicon Graphics Incorporated | - | Human Genome |
| SGML | Standard Generalized Markup Language | - | Human Genome |
| SGRAM | Synchronous Graphic RAM | - | Human Genome |
| SIG | Special Interest Group | - | Human Genome |
| SIMD | Single Instruction Multiple Data | - | Human Genome |
| SIMM | Single In-line Memory Module | - | Human Genome |
| SIP | Single In-line Package | - | Human Genome |
| SLDRAM | SyncLink DRAM | - | Human Genome |
| SLED | Single Large Expensive Disk | - | Human Genome |
| SLIP | Serial Line Internet Protocol | - | Human Genome |
| SMART | Self-Monitoring, Analysis And Reporting Technology | - | Human Genome |
| SMB | Server Message Block | - | Human Genome |
| SMDS | Switched Multimegabit Data Services | - | Human Genome |
| SMIF | Stream-based Model Interchange Format | - | Human Genome |
| SMIL | Synchronized Multimedia Integration Language | - | Human Genome |
| SMP | Simple Management Protocol | - | Human Genome |
| SMP | Symmetric Multiprocessing | - | Human Genome |
| SMS | Systems Management Server | - | Human Genome |
| SMTP | Simple Mail Transfer Protocol | - | Human Genome |
| SNA | Systems Network Architecture | - | Human Genome |
| SNMP | Simple Network Management Protocol | - | Human Genome |
| SOAP | Simple Object Access Protocol | - | Human Genome |
| SOC | System-on-a-Chip | - | Human Genome |
| SOHO | Small Office/Home Office | - | Human Genome |
| SONET | Synchronous Optical Network | - | Human Genome |
| SPARC | Scalable Processor Architecture | - | Human Genome |
| SPE | Superparamagnetic Effect | - | Human Genome |
| SPEC | Standard Performance Evaluation Corporation | - | Human Genome |
| SPID | Service Profile (Provider) Identification | - | Human Genome |
| SPIM | Spam Over Instant Messaging | - | Human Genome |
| SPX | Sequenced Packet Exchange | - | Human Genome |
| SQL | Structured Query Language | - | Human Genome |
| SRAM | Static Random Access Memory | - | Human Genome |
| SSD | Solid-state Disk | - | Human Genome |
| SSI | Server-Side Include | - | Human Genome |
| SSL | Secure Sockets Layer | - | Human Genome |
| SSSCA | Security Systems Standards And Certification Act | - | Human Genome |
| ST506/412 | Seagate Technologies 506 And 412 Controller (older Technology) | - | Human Genome |
| SVC | Switched Virtual Circuit | - | Human Genome |
| SVG | Scalable Vector Graphics | - | Human Genome |
| SVGA | Super Video Graphics Array | - | Human Genome |
| SWISH | Simple Web Indexing System For Humans | - | Human Genome |
| SYN | Synchronize Sequence Number | - | Human Genome |
| SYSOP | System Operator | - | Human Genome |
| Service | prior to October 1997)
| - | Human Genome |
| SAC | Service Access Code
| - | Human Genome |
| SAFER | split access flexible egress routing
| - | Human Genome |
| SAG | Senior Advisory Group
| - | Human Genome |
| SALT | Speech Application Language Tags
| - | Human Genome |
| SAM | SCSI-3 Architecture Model
| - | Human Genome |
| SANS/FBI | SysAdmin, Audit, Network, Security Institute/Federal Bureau of Investigation
| - | Human Genome |
| SAR | Security Assessment Report
| - | Human Genome |
| SASS | Shared Access for Switched Services
| - | Human Genome |
| SatAA | satellite access arrangement
| - | Human Genome |
| SatAS | Satellite Access Service
| - | Human Genome |
| SB | service broker
| - | Human Genome |
| SBP | serial bus protocol
| - | Human Genome |
| SB/SDB | Small Business/Small Disadvantaged Business
| - | Human Genome |
| SBU | sensitive but unclassified
| - | Human Genome |
| SC | service coordinator
| - | Human Genome |
| SCA | Security Control Assessment
| - | Human Genome |
| SCAMP | security call analysis and monitoring platform
| - | Human Genome |
| SCCP | skinny client control protocol
| - | Human Genome |
| SCE | service creation environment
| - | Human Genome |
| SCI | sensitive compartmented information
| - | Human Genome |
| SCIF | Sensitive Compartmented Information Facility
| - | Human Genome |
| SCR | selective call rejection
| - | Human Genome |
| SCRM | Supply Change Risk Management
| - | Human Genome |
| SDDN | software defined data network
| - | Human Genome |
| SDI | Strategic Defense Initiative
| - | Human Genome |
| SDLC | Software Development Life Cycle
| - | Human Genome |
| SDN | software defined network
| - | Human Genome |
| SDN-NRA | Software Defined Network-Network Remote Access
| - | Human Genome |
| SDN-SMS | Software Defined Network-Service Management System
| - | Human Genome |
| SDP | Service Delivery Point
| - | Human Genome |
| SDPP | Service Delivery Project Plan
| - | Human Genome |
| SDS | Switched Data Service
| - | Human Genome |
| SECAM | Système Electronique Couleur Avec Memoire
| - | Human Genome |
| SED | service enabling device
| - | Human Genome |
| SEMP | Systems Engineering Management Plan
| - | Human Genome |
| SEN | Security Enforcement Node
| - | Human Genome |
| SES | SCSI enclosure services
| - | Human Genome |
